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KMID : 0613820130230111325
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Journal of Life Science
2013 Volume.23 No. 11 p.1325 ~ p.1335
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Bioinformatic Analysis of the Canine Genes Related to Phenotypes for the Working Dogs
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Kwon Yun-Jeong
Eo Jung-Woo
Choi Bong-Hwan
Choi Yu-Ri
Gim Jeong-An
Kim Da-hee
Kim Tae-Hun
Seong Hwan-Hoo
Kim Heui-Soo
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Abstract
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Working dogs, such as rescue dogs, military watch dogs, guide dogs, and search dogs, are selected by in-training examination of desired traits, including concentration, possessiveness, and boldness. In recent years, genetic information has been considered to be an important factor for the outstanding abilities of working dogs. To characterize the molecular features of the canine genes related to phenotypes for working dogs, we investigated the 24 previously reported genes (AR, BDNF, DAT, DBH, DGCR2, DRD4, MAOA, MAOB, SLC6A4, TH, TPH2, IFT88, KCNA3, TBR2, TRKB, ACE, GNB1, MSTN, PLCL1, SLC25A22, WFIKKN2, APOE, GRIN2B, and PIK3CG) that were categorized to personality, olfactory sense, and athletic/learning ability. We analyzed the chromosomal location, gene-gene interactions, Gene Ontology, and expression patterns of these genes using bioinformatic tools. In addition, variable numbers of tandem repeat (VNTR) or microsatellite (MS) polymorphism in the AR, MAOA, MAOB, TH, DAT, DBH, and DRD4 genes were reviewed. Taken together, we suggest that the genetic background of the canine genes associated with various working dog behaviors and skill performance attributes could be used for proper selection of superior working dogs.
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KEYWORD
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Chromosomal location, expression, gene-gene network, Gene Ontology, working dogs
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